Blood oxygenation level-dependent contrast Definition
BOLD contrast has emerged as one of the most potent noninvasive tools for mapping brain function and has been widely used to explore physiological, pathological changes and mental activity in the brain. The physiological basis underlying the BOLD contrast is based on the neurovascular coupling. Neuronal activity leads to a hemodynamic response resulting in a concentration change of oxygenated and deoxygenated hemoglobin. As oxygenated and deoxygenated hemoglobin have different magnetic properties, this concentration change can be detected using MRI. Thus, the MR image contrast depends on the blood oxygenation level.
► Functional MRI
► Pharmacological fMRI
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