Concluding Comments

Within the last two decades, the concepts of constitutive receptor activity and inverse agonism have gone from being pharmacological curiosities to accepted paradigms in drug and receptor behavior. Constitutively active receptors are now used routinely in drug discovery research in order to classify potential hits in terms of their possible spectrum of efficacies. Moreover, most compounds that have previously been classed as (neutral) antagonists are very likely to be inverse agonists. However, the clinical relevance of inverse agonists remains largely unknown. The challenge now is to be able to better correlate improved mechanistic understanding of the pluridimen-sional nature of drug efficacy with improved clinical outcomes.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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