Cyp3a4

Inhibitor of noradrenaline uptake

Risperidone

CYP2D6, CYP3A4

Antagonist of dopamine D2, 5-HT2 receptors and adrenoceptors

Rivastigmine

Acetylcholine esterase

Inhibitor of acetylcholine and butyrylcholine esterase

Sertindole

CYP3A4, CYP2D6

Antagonist of dopamine and 5-HT2 receptors, blockade of potassium channels

Sertraline

CYP2B6, CYP2C19, CYP2C9, CYP2D6

Inhibitor of serotonin uptake

Sulpiride

Not metabolized

Antagonist of dopamine D2 receptors

Temazepam

Glucuronyl transferase

Allosteric GABAA receptor stimulation

Thioridazine

CYP2D6, CYP1A2, CYP2C19

Inhibitor of acetylcholine, dopamine D2, 5-HT2 receptors and ^-adrenoceptors

Trimipramine

CYP2C19, CYP2D6, CYP2C9

Inhibitor of histamine HI and dopamine D2 receptors

Tranylcypromine

Monoamine oxidase

Irreversible inhibitor of monoamine oxidase

Drug Interactions. Table 1. (continued)

Drug

Enzymesa

Mechanisms of action (targets)

Trazodone

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