Amisulpride is a benzamide derivative and is a second-generation antipsychotic with high affinity for D2 and D3 receptors. Its pharmacology is unusual in that at low doses, amisulpride preferentially blocks presynaptic D2 receptors, while at high dose it acts as an antagonist at postsynaptic D2 receptors. Amisulpride is used for the treatment of positive and negative symptoms of ► schizophrenia, as well as the management of dysthymia. Its therapeutic and safety profile is similar to that of the atypical antipsychotic ► risperidone, but amisulpride is associated with less weight gain and endocrine disturbance.
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