This essay delineates the pharmacological, physiological, pathological and therapeutical relevance of ► neuroactive steroids. These steroids are endogenous or synthetic compounds that can cross the ► blood-brain barrier and rapidly alter neuronal excitability via membrane receptors. We focus on neuroactive steroids that have specific binding sites on g-aminobutyric acid type-A (► GABAA) receptors which directly influence both synaptic and extrasynaptic transmission and indirectly alter many physiological processes including ► hypothalamic-pituitary-adrenal (HPA) axis function, inflammation, and myelin formation. Neuroactive steroid levels are modulated by stress, ovarian cycle, pregnancy, as well as numerous pharmacological agents. We summarize the sites of neu-roactive steroid actions, the systemic and molecular consequences of these actions, and the potential therapeutic relevance of their effects for neuropsychiatric disease.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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