Pargyline is an irreversible inhibitor of monoamine oxidase used for the treatment of depression with selectivity for MAO-B. It is less effective than ► tricyclic antidepres-sants and its interactions with dietary amines lead to serious toxicity. For example, foods such as cheeses that contain tyramine must not be consumed. It can also interact dangerously with other drugs including tricyclic antidepressants. Its use is now very limited, mainly to cases of depression that do not respond to newer anti-depressants such as the inhibitors of the reuptake of serotonin and norepinephrine. Other side effects include hypotension, sedation, and weight gain.
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