Secobarbital is an intermediate- to short-acting (half-life 15-40 h) barbiturate drug that is used primarily as a hypnotic agent to treat insomnia. It is also used as a premedica-tion before surgery and for the emergency management of seizures. Secobarbital is an agonist at ► GABAa receptors thereby increasing inhibitory ► GABAergic transmission in the CNS. It binds to a distinct site upon the GABAA receptor ion channel complex increasing the duration of time for which the Cl_ channel is open. Secobarbital, like other barbiturate drugs, has a narrow therapeutic window, that is, a small difference between the minimum effective dose for sedation and maximum tolerated dose producing coma and death. Long-term use of this drug is contraindicated because of its ability to produce tolerance and dependence, and abrupt withdrawal from chronic treatment precipitates a life-threatening withdrawal syndrome. It is used illicitly for the purposes of getting high, to reduce anxiety, to counteract the effects of stimulant drugs, for example, cocaine, ecstasy, and in suicide.

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Sleeping Sanctuary

Sleeping Sanctuary

Salvation For The Sleep Deprived The Ultimate Guide To Sleeping, Napping, Resting And  Restoring Your Energy. Of the many things that we do just instinctively and do not give much  of a thought to, sleep is probably the most prominent one. Most of us sleep only because we have to. We sleep because we cannot stay awake all 24 hours in the day.

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