Definition

Histones are the main protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. There are a total of six classes of histones (H1, H2A, H2B, H3, H4, and H5). Covalent modification of histones (e.g., their acetylation, methylation, phosphorylation, etc.) controls the degree to which chromatin is active or inactive.

Subhash C. Pandey

Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, IL, USA

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