Memory is central to our understanding about ourselves with a personal history, and consequently memory loss has a devastating impact on both the individual concerned and their carers. Thus, one of the major goals in neuroscience is to understand the neural mechanisms that underlie the formation of memory within different brain manner.

regions. ► Long-term potentiation (LTP), which is the long-lasting increase in synaptic strength produced by trains of stimuli, has been proposed to provide a suitable cellular model of information storage in the brain. This argument is based on the defining characteristics of LTP (i.e., specificity, associativity, and persistence) and the demonstration that psychoactive drugs that block LTP have been shown to impair memory. This chapter presents the evidence that the mechanisms that underlie LTP may be the same as those that are responsible for the formation of memory, with a focus on the impact of specific pharmacological manipulations. Memory formation clearly relies on fast, long-lasting changes in the connections between neurons; however, whether LTP, as per current studies, underlies learning and memory is still unproven and consequently a matter for ongoing debate.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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