Conditioned place preference (CPP)/conditioned place aversion (CPA) is a behavioral paradigm largely based on principles of ► classical (Pavlovian) conditioning. For conditioning, a distinct set of environmental cues is explicitly paired with a particular drug or nondrug treatment, and a distinctly different set of environmental cues is paired with a control treatment. Most commonly, treatment and control pairings are repeated several times, usually once per day. Over the course of conditioning, the rewarding or aversive treatment effects will become associated with the particular set of cues paired with the treatment, such that in a post-conditioning test trial, these cues will elicit approach (when the treatment had rewarding effects) or avoidance (when the treatment had aversive
Conditioned Place Preference and Aversion. Fig. 1.
Common design of a conditioning apparatus (top panel) and illustration of the conditioning principle: one compartment is paired with vehicle administration (middle panel), and one compartment is paired with drug administration (bottom panel). Rat cartoon by Axel Strobl.
effects), resulting in a conditioned preference or aversion for the treatment-paired environment (or "place") (Fig. 1).
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