► Histone deacetylase (HDAC) inhibitors are compounds that have the ability to prevent the deacetylation of lysine residues found within the N-terminal tails of histone proteins (Nuclear proteins that DNA wraps around to form the chromatin structure which organizes into the nucleosome; see Fig. 1). These compounds were initially developed to treat cancers (Lee et al. 2008), but have recently been used to treat various brain disorders in animal models, suggesting that HDAC inhibitors may potentially develop into novel therapeutic agents (Abel and Zukin 2008; Kazantsev and Thompson 2008).
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