Double Blinded Study

Synonyms

Double-blind study; Double-masked studies Definition

Blinded studies are part of a scientific method to prevent research outcomes from being influenced by various biases such as patient expectations (placebo effect) and experimenter expectancy (observer bias). The term blind is a figurative extension of the literal idea of blindfolding someone. The opposite of a blinded trial is an open trial. An open trial or open-label trial is a clinical trial in which both the researchers and participants know which treatment is being administered. There can be varying degrees of blinding such as single-blind, double-blind, triple-blind, etc. Double-blinded study is a term used to described a study in which both the investigator or the participant are blind to (unaware of) the nature of the treatment the participant is receiving. In a doubleblind experiment, neither the individuals nor the researchers know who belongs to the control group and the experimental group. Double-blind trials are thought to produce objective results, since the expectations of the researcher and the participant about the experimental treatment such as a drug do not affect the outcome. Double-blinded studies are often chosen when a treatment shows particular promise and the illness involved is serious. It can be hard to recruit human subjects for a blinded study of a promising treatment when one group will receive only a placebo or an existing medicine.

Cross-References

► Clinical Antipsychotic Trials

► Randomised Controlled Trial

► Relaps Prevention Study Design

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