Doxepin

Definition

Doxepin is a ► tricyclic antidepressant with a tertiary amine chemical structure. It acts by inhibiting the reup-take of serotonin and norepinephrine. Its primary use is in the treatment of depression, but it is also occasionally used in treating anxiety disorders and insomnia. Usage of doxepin has declined in recent years in conjunction with the general decline in the use of tricyclics. Doxepin causes marked sedation; otherwise, its side effect profile is similar to that of other tricyclics, including cardiovascular effects and anticholinergic effects (e.g., constipation, dry mouth, blurred vision, urinary retention). As with other tricyclics, its potential for lethality in overdose is high.

Cross-References

► Antidepressants

► Tricyclic Antidepressants

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