Genetic Models

One of the most investigated animal models of ADHD is the spontaneously hypertensive rat (SHR), an inbred genetic model derived from the Wistar Kyoto (WKY) rat. Hyperactivity and impulsivity in the SHR develop over repeated testing and are particularly evident in settings with a low rate of reinforcement (Sagvolden 2000). These traits are present before the SHR develops hypertension and remain stable during adulthood. Compared with Sprague-Dawley (SD) rats, SHR show a neurochemical profile characterized by subcortical hyperdopaminergic tone and reduced ► noradrenaline (NE) function in the

Attention Deficit Hyperactivity Disorders: Animal Models. Table 1. Summary of selected models of ADHD, their behavioral characteristics, and tasks used to assess them.


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