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reflecting the gradual increase in tissue concentration of drug during the ejection period. If a series of such responses are obtained, reaching the same maximum amplitude, they can be readily characterized by the T50 value (Fig. 3). Moreover, T50 value is easier to measure accurately than a response size. Thus, it can be very difficult to obtain reproducible graded response amplitudes to some very potent compounds such as amino acids. Any changes in ► firing rate during a response, which ideally should be of the plateau variety, may further complicate any assessment of the response size, whereas in the determination of T50 values, all responses increase to the same maximal level, which maybe 100% inhibition or a clear maximal plateau of excitation tending toward overdepolarization.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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