The nucleus accumbens is a small brain region located in the ventral striatum. It is a major projection area (terminal field) for dopaminergic neurons located in the ventral tegmental area of the midbrain. It is thought to play an important role in many behavioral and psychological processes, including ► reward-related behavior, incentive motivation, memory processing and habit formation, and in dopamine-mediated psychotic symptoms in ► schizophrenia. It has been implicated in the reinforcing effects produced by various natural stimuli such as food, water, and sexual opportunity, as well as by ► drugs of abuse. In
Number-needed-to-harm (NNH) is a clinically useful measure for the difference between treatment groups regarding a negative outcome, such as all-cause discontinuation, relapse, or number of patients with significant weight gain. It denotes the number of patients that need to be exposed to a treatment until one additional negative event of interest occurs in excess of the rate in the comparator group. The NNH is calculated by subtracting the percent rate of the comparator group from the percent rate of the active treatment group and dividing the difference by 1. An NNH of below 10 is generally considered clinically meaningful.
► Randomized Controlled Trials
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