Pharmacokinetics

Following oral ingestion with or without food, atomox-etine is rapidly absorbed with peak plasma levels occurring at approximately 1-1.5 h (Sauer et al. 2005). With regular dosing, steady-state concentrations are obtained by day 10, with trough plasma concentrations of ~30-40°ng/mL. The metabolism of atomoxetine is dependent primarily on the hepatic ► cytochrome P450 (CP450) system, which is highly polymorphic such that individuals can be classified into extensive metabolizers (EMs) or poor metabolizers (PMs) (Trzepacz et al. 2008). The majority of people (>90%) are EMs, while rarer PM individuals or individuals taking enzyme inhibitor medications, show fivefold greater peak plasma concentration and slower ► half-life elimination. Following a single oral dose, EMs exhibit an atomoxetine half-life of ~5.2 h with plasma clearance of ~0.35 L/h/kg, while PMs exhibit half-life of ~21.6 h and clearance of ~0.3 L/h/kg.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

Get My Free Ebook


Post a comment