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Easy manufacture of probes
No enzymatic degradation of transmitters in samples
Coupling to chemical methods of analysis (HPLC, mass spectrometry, capillary electrophoresis, etc.)
Possibility of local administration of drugs Possibility of concurrent determination of drugs after systemic administration Dual probe approaches Possibility of concurrent recording of electrical activity
Concurrent study of behavior in freely-moving animals
Invasive procedure: causes neuronal death and reactive gliosis
Limited spatial resolution
Limited temporal resolution
Analytical difficulties with some transmitters
Low membrane recoveries with high molecular weight compounds
release of dopamine simultaneously recorded by microdialysis. Brain
Ungerstedt U (1984) Measurement of neurotransmitter release by intra-cranial dialysis. In: Marsden CA (ed) Measurement of neurotrans-mitter release in vivo. Wiley, Chichester, pp 81-105
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