S

effect remains to be determined for most cases. Given the relevance of synaptic plasticity for cognitive and emotional processes, this form of neuronal plasticity is no doubt a major contributor to the behavioral effects induced by psychopharmacological drugs.

Cross-References

► Extracellular Recording

► Intracellular Recording

► Long Term Depression

► Long Term Potentiation

► Nicotinic Agonists and Antagonists

► Tonic Signals

References

Abraham WC (2008) Metaplasticity: tuning synapses and networks for plasticity. Nat Rev Neurosci 9:387-399 Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P (2008) Cell type-specific regulation of DARPP-32 phos-phorylation by psychostimulant and antipsychotic drugs. Nat Neu-rosci 11:932-939

Berlucchi G, Buchtel HA (2009) Neuronal plasticity: historical roots and evolution of meaning. Exp Brain Res 192:307-319 Berry-Kravis E, Hessl D, Coffey S, Hervey C, Schneider A, Yuhas J, Hutchison J, Snape M, Tranfaglia M, Nguyen DV, Hagerman R (2009) A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet 46:266-271 Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S (2007) Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci 35:183-193

Pittenger C, Duman RS (2008) Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33:88-109 Stone JM, Morrison PD, Pilowsky LS (2007) Glutamate and dopamine dysregulation in schizophrenia - a synthesis and selective review. J Psychopharmacol 21:440-452 Turner TJ (2004) Nicotine enhancement of dopamine release by a calcium-dependent increase in the size of the readily releasable pool of synaptic vesicles. J Neurosci 24:11328-11336 Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64:355-405

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