Sulpiride is a ► typical antipsychotic based on antagonism of postsynaptic D2 dopamine receptors. Agonism at the gamma-hydroxybutyrate receptor may contribute to its antipsychotic properties. Sulpiride has fewer ► extrapyramidal side effects, but also reduced antipsychotic potency, as compared with many other typical antipsy-chotics. At lower doses than used for antipsychotic treatment, its prominent action is presynaptic dopamine autoreceptor antagonism, giving rise to antidepressant and stimulating effects. Secondary clinical uses are thus treatment of depression and vertigo. Sulpiride is currently not approved in the USA and Canada. Together with the atypical antipsychotic ► sultopride, sulpiride falls under the chemical class of benzamides.


► Antipsychotics

► First-Generation Antipsychotics

Was this article helpful?

0 0
Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

Get My Free Ebook

Post a comment