Sulpiride is a ► typical antipsychotic based on antagonism of postsynaptic D2 dopamine receptors. Agonism at the gamma-hydroxybutyrate receptor may contribute to its antipsychotic properties. Sulpiride has fewer ► extrapyramidal side effects, but also reduced antipsychotic potency, as compared with many other typical antipsy-chotics. At lower doses than used for antipsychotic treatment, its prominent action is presynaptic dopamine autoreceptor antagonism, giving rise to antidepressant and stimulating effects. Secondary clinical uses are thus treatment of depression and vertigo. Sulpiride is currently not approved in the USA and Canada. Together with the atypical antipsychotic ► sultopride, sulpiride falls under the chemical class of benzamides.
► First-Generation Antipsychotics
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