This chapter reviewed the main behavioral and neuro-chemical characteristics of some of the most investigated rodent models of ADHD. The collection of animal models of ADHD described here is far from complete, but is illustrative of the different approaches. Table 1 summarizes some of the behavioral tasks used to characterize ADHD-like symptoms - namely, impulsivity, hyperactiv-ity, and attention deficits - in selected animal models and the drugs that were efficacious in ameliorating the performance of the models when compared with control animals. Some of these behavioral tasks — borrowed from clinical neuropsychological research — have highlighted the translational value of ADHD research in animals. They not only prove useful in the definition of the behavioral phenotype under investigation, but also have the potential to investigate the mechanisms of action of drugs used in ADHD. Their use, in conjunction with appropriate animal models of ADHD, can help in discovering new treatments with fewer side effects and enhanced therapeutic value.
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