Tiagabine

Definition

Tiagabine is an anticonvulsant drug that is used as a third-line adjunct medication for the treatment of partial seizures in adults and children. It acts by selectively inhibiting the GABA transporter 1 reuptake inhibitor. Thus, it enhances inhibitory ► GABAergic neurotransmission and prevents propagation of neuronal impulses and seizures. Tiagabine reduces seizure frequency but does not produce freedom from seizures and has a low tolerability, for example, low anticonvulsant efficacy compared to other third-line antiepileptic drugs. It also has a high rate of side effects including dizziness, lack of energy, nausea, and nonconvulsive status epilepticus. Open-label investigations have suggested that tiagabine may be used as an add-on medication in anxiety disorders, for example, ► generalized anxiety disorder, and for the treatment of alcohol dependence. It is thought that tiagabine may reduce both ► anxiety and alcohol ► craving in withdrawal, possibly via indirect GABA inhibition of the ► meso-limbic dopamine system. However, its efficacy for these indications has not yet been confirmed in double-blind placebo-controlled studies.

Cross-References

► Alcohol Abuse and Dependence

► Anticonvulsants

► Generalized Anxiety Disorder

► Placebo Effect

► Randomized Controlled Trials

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