Tiagabine is an anticonvulsant drug that is used as a third-line adjunct medication for the treatment of partial seizures in adults and children. It acts by selectively inhibiting the GABA transporter 1 reuptake inhibitor. Thus, it enhances inhibitory ► GABAergic neurotransmission and prevents propagation of neuronal impulses and seizures. Tiagabine reduces seizure frequency but does not produce freedom from seizures and has a low tolerability, for example, low anticonvulsant efficacy compared to other third-line antiepileptic drugs. It also has a high rate of side effects including dizziness, lack of energy, nausea, and nonconvulsive status epilepticus. Open-label investigations have suggested that tiagabine may be used as an add-on medication in anxiety disorders, for example, ► generalized anxiety disorder, and for the treatment of alcohol dependence. It is thought that tiagabine may reduce both ► anxiety and alcohol ► craving in withdrawal, possibly via indirect GABA inhibition of the ► meso-limbic dopamine system. However, its efficacy for these indications has not yet been confirmed in double-blind placebo-controlled studies.


► Alcohol Abuse and Dependence

► Anticonvulsants

► Generalized Anxiety Disorder

► Placebo Effect

► Randomized Controlled Trials

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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