Tracer Dose Definition

A very small concentration at which a radiotracer is administered, such that the presence of the radiotracer itself does not noticeably influence the pharmacology or pharmacokinetics of the process being imaged. For rever-sibly binding ligands, the usual convention is that the peak binding of the radioligand does not exceed 5% of the available receptor pool. Because the equilibrium bound to free ligand ratio is B/F = Bmax/(F + KD) and the free ligand associated with 5% occupancy is approximately 5% of KD, this restriction insures that binding potential will be measured accurately to within 5%. From the data-fitting perspective, the use of tracer dose also insures that the linearization of the mass action law applied in the compartment model is justified.

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Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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