Volume of Distribution

Volume Transmission

Synonyms

Apparent volume of distribution; VD Definition

The volume of distribution (VD) is the fictitious (theoretical) volume, expressed in liter or in liter per kilogram, in which a drug would have been distributed by supposing that its concentration is homogeneous, that is, the average tissue concentration is identical to that of the plasma. It is expressed as VD = dose/C0 (initial concentration). For example, after intravenous injection of 100 mg of a drug whose initial concentration, C0, in plasma is 10 mg/L, the VD is of 10 L.

Cross-References

► Bioavailability

► Distribution Phase

► Elimination Half-Life or Biological Half-Life

► Pharmacokinetics

Definition

Volume transmission in the brain usually refers to actions of ► neurotransmitters or ► neuropeptides at a distance well beyond their release sites from cells or synapses. It is established that some peptides such as b-endorphin and ► enkephalins can act on neurons at distances much greater than a synapse but the actual range of influence is still unknown.

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