Neurotransmitter And Neuropeptide Systems Serotonergic System

Parkinson Disease

Largely on the basis of the observation that most current effective antidepressants and antipsychotics target these systems, the monoaminergic systems (e.g., serotonin, norepinephrine, dopamine) have been extensively studied. Serotonin (5-HT) was given that name because of its activity as an endogenous vasoconstrictor in blood serum (Rapport et al. 1947). It was later acknowledged as being the same molecule (secretin) found in the intestinal mucosa and that is secreted by chromaffin cells...

Neuroanatomy Of The Dopamine System

Anatomia Emocjonalna

The precursor for dopamine (DA), and all catecholamines, is the amino acid tyrosine. The rate-limiting step in DA synthesis is the conversion of tyrosine to L-dihydroxyphenylalanine (L-dopa) by the enzyme tyrosine hydroxylase. DA is then formed by decarboxylation of L dopa via the enzyme L-aromatic amino acid decarboxylase. DA neurotransmission is terminated through the actions of the dopamine transporter (DAT) (Jaber et al. 1997), although in some areas where the amount of DAT is low,...