Anger and Aggression

Diminished serotonergic activity has been implicated in the personality features of impulsivity, anger, hostility, and aggression (Coccaro et al. 1989). These clinical attributes best associate with DSM-IV (American Psychiatric Association 1994) Cluster B personality disorders. Fluoxetine reduced impulsivity in small groups of patients with borderline personality disorder (Cornelius et al. 1991; Norden 1989). Fluoxetine significantly reduced anger attacks in patients with and without depression (Fava et al. 1991, 1993, 1996; Rubey et al. 1996; Salzman et al. 1995).

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