The use of drugs in psychopharmacology can be problematic as a result of pharmacokinetic and pharmacodynamic variability in the dose-effect relationship. Some sources of variability can be controlled through application of pharmacokinetic principles in dosage regimen design and therapeutic drug monitoring. Understanding of pharmacodynamic principles contributes to individualization of dosage regimens. The database on the genetic contribution to drug response and the interactions between drugs is rapidly expanding. Future application of this knowledge will further enhance pharmacotherapy for mentally ill patients.

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