Frequency of poor metabolizers or dysfunctional phenotypes


5%-10% Caucasians 3% Blacks

1% Asians

1% Arabs

Clinical consequences Example substrates

Increased drug bioavailability

High drug concentrations; possible toxicity

Digoxin, fexofenadine, methadone, olanzapine, aripiprazole, risperidone, paliperidone, citalopram, sertraline, amitriptyline, buspirone, clozapine, fluvoxamine, haloperidol, nortriptyline, venlafaxine

Desipramine, nortriptyline, codeine, dextromethorphan

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