Diffusion Tensor Imaging and Tractography

Most of the previously described volumetric methods focus on gray matter structures as opposed to diffusion tensor imaging (DTI) and associated techniques that image white matter. DTI technologies image water diffusion to study the directionality and integrity of white matter connections between different locations of the brain (Kubicki et al. 2007). These studies advance the hypothesis that psychiatric disorders are characterized by altered connectivity ("disconnection syndromes"). These studies are beginning to help us understand the basis of cerebral organization and connectivity and how it might be affected in psychiatric disorders such as autism (Alexander et al. 2007), late-life depression

(Taylor et al. 2007), and schizophrenia (Nestor et al. 2007).

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