DNA Replication

Chromosomal DNA must be replicated to coordinate with cell division. Replication begins at a sequence called the origin of replication. It involves the separation of the double helix DNA strands over a short length and the binding of enzymes, including DNA and RNA polymerases. During DNA replication, each existing strand of DNA serves as a template for the synthesis of a new double helix that contains one old strand and one strand that is newly synthesized but complementary. This process is known as semiconservative replication. In the process of cell division, each of the 46 double helices is replicated and folded into chromosomes.

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