Blood capillary Tryptophan

High-affinity tryptophan transport p-Chlorophenylalanine I HVd^oxy'ase ---1 inhibitor

■Tryptophan hydroxylase 5-H y d roxyt ry pto p h a n cr-Methyl 5-HTP

Decarboxylase inhibitor

5-HTP decarboxylase

Reserpine Tetra benazine

5-HT releasers p-Chlorophenylalanine Fenfluramine

Terminal auto receptor

Postsynaptic receptor

Tranylcypromine Pargyline

Reuptake inhibitors

Tranylcypromine Pargyline


Reuptake inhibitors

Copyright © American Psychiatric Publishing, Inc., or American Psychiatric Association, unless otherwise indicated in figure legend. All rights reserved.

For clarity, drugs acting at 5-HT receptors have been omitted. 5-HIAA = 5-hydroxyindoleacetic acid; 5-HTP = 5-hydroxytryptophan; MAO = monoamine oxidase; MAOI = monoamine oxidase inhibitor.

Source. Reprinted from Marsden CA: "The Neuropharmacology of Serotonin in the Central Nervous System," in Selective Serotonin Re-Uptake Inhibitors. Edited by Feighner JP, Boyer WF. Chichester, England, Wiley, 1991, pp. 11-35. Copyright 1991, John Wiley and Sons Limited. Reproduced with permission.

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