Info

Absorption altered by fast or fed status

No

No

Yes

No

No

No

Altered half-life in geriatric patient

No

Yes

Yes

Yes

No

Yes

Reduced clearance in renal patients3

±

+

±

±

±

±

Note. NA = not applicable. a+ = yes; ± = somewhat/mixed.

The relatively long half-life of fluoxetine confers greater protection from the discontinuation syndrome that is associated with abrupt discontinuation or noncompliance related to interruption of treatment than more rapidly cleared SSRIs. Conversely, more prolonged vigilance for drug-drug interactions following discontinuation is required for fluoxetine; for example, a 5-week washout from fluoxetine is recommended before initiating an MAOI (Ciraulo and Shader 1990; Lane and Baldwin 1997). Variability in drug half-life is associated with a range in time to steady-state plasma concentrations, which does not clearly predict or correlate with onset of antidepressant activity.

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