Synaptic turnover of serotonin secretion is regulated by two processes—by SERT-mediated reuptake and by negative feedback mediated through serotonin type 1A (5-HT1A) autoreceptors. Downregulation of 5-HT1A receptors may be associated with antidepressant efficacy and might also explain the delay in the onset of clinical response after being started on SSRIs (Blier and Ward 2003). Radioligands such as [11C] WAY-100865 have been used to study the dynamics of 5-HT1 receptors (Fisher et al. 2006). This methodology has also made contributions to better understanding how serotonergic system imbalances disrupt mood-regulating neural circuitry, resulting in depressive disorders (Fisher et al. 2006).
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