Neurotransmitter Binding Sites

PET imaging has been used to identify binding sites of neurotransmitters of relevance to psychiatric disorders, in order to characterize patients and inform treatment decisions based on mechanisms of drug action. For instance, studies with ligands that bind to D2 receptors have informed us that lower binding affinity, faster dissociation, and optimal occupancy at usually prescribed doses of D2 receptor antagonists might form the basis of atypical antipsychotic drug action (Kapur and Remington 2001). Studies reporting increased binding of serotonin type 2A (5-HT2A) receptors using agents such as 18F-altanserin in frontal cortex (Brodmann area [BA] 9) and their association with increased pessimism and self-injurious and suicidal behavior have added to our understanding of depression (Meyer et al. 2003). Alterations in the function of 7-aminobutyric acid (GABA) systems in posttraumatic stress

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