Imipramine has been used for treatment of nocturnal enuresis in children with FDA approval, and controlled trials indicate that it is clearly effective (Rapoport et al. 1980). The dose of imipramine is usually 25-50 mg at bedtime. Amitriptyline and nortriptyline also appear to be useful, although they are not approved for use in this disorder. The mechanism of action is unclear but may in part be anticholinergic. It is not clear, however, that the risk of cardiac problems would be substantially less with tricyclics other than desipramine in children younger than 12 years, although the low doses required may reduce this risk.
Tricyclic antidepressant drugs have been extensively studied in patients with schizophrenia. However, in the absence of a major depressive syndrome, these agents appear to be of limited value (Siris et al. 1978).
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