Pathological Cerebral Deposits

Degenerative disorders such as Alzheimer's disease have acquired critical relevance, given the larger proportion of aging population in the modern society. Since the pathological changes associated with neurodegeneration (such as beta-amyloid deposits, neurofibrillary tangles, and decreased metabolic activity) often precede clinical disease by several decades, early identification of these changes is of paramount importance. Three different ligands have been reported recently, all of them with the ability to detect intracerebral beta-amyloid deposition with high accuracy using PET radiotracer technology: [18F] FDDNP (Small et al. 2006), [11C] PIB (Pittsburgh Compound-B) (Klunk et al. 2004), and [11C] SB (Ono et al. 2003). Such compounds have potential clinical applications in that they may help identify patients with mild cognitive impairment (MCI) who are at increased risk of converting to dementia (Mathis et al. 2005).

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment