Pediatric Obsessive Compulsive Disorder

Sertraline is approved for use in children for the treatment of OCD. In a 12-week double-blind, placebo-controlled, parallel-group, multicenter study, March et al. (1998) found that children and adolescents treated with sertraline showed significant improvement on several efficacy measures, compared with placebo. One hundred eighty-seven subjects (107 children, ages 6-12 years, and 80 adolescents, ages 13-17 years) were randomly assigned to receive either sertraline (92 subjects) or placebo (95 subjects). The mean dosage at endpoint was 167 mg/day for sertraline and 180 mg/day for placebo. Subjects who were treated with sertraline showed significantly greater improvement than placebo on the Y-BOCS (-6.8 and -3.4, respectively; P = 0.005), NIMH-GOCS (-2.2 and -1.3, respectively; P = 0.02), and CGI-I (2.7 and 3.3, respectively; P = 0.002). The authors reported a small number of dropouts because of adverse events and overall found sertraline to be a safe, well-tolerated treatment for this age group. In children and adolescents treated with sertraline over 12 months (at doses between 50-200 mg/daily over 52 weeks), evidence suggests that acute response can convert to full or partial remission of symptoms with longer-term treatment (Wagner et al. 2003).

Nicotine Support Superstar

Nicotine Support Superstar

Stop Nicotine Addiction Is Not Easy, But You Can Do It. Discover How To Have The Best Chance Of Quitting Nicotine And Dramatically Improve Your Quality Of Your Life Today. Finally You Can Fully Equip Yourself With These Must know Blue Print To Stop Nicotine Addiction And Live An Exciting Life You Deserve!

Get My Free Ebook

Post a comment