Pediatric Obsessive Compulsive Disorder

Sertraline is approved for use in children for the treatment of OCD. In a 12-week double-blind, placebo-controlled, parallel-group, multicenter study, March et al. (1998) found that children and adolescents treated with sertraline showed significant improvement on several efficacy measures, compared with placebo. One hundred eighty-seven subjects (107 children, ages 6-12 years, and 80 adolescents, ages 13-17 years) were randomly assigned to receive either sertraline (92 subjects) or placebo (95 subjects). The mean dosage at endpoint was 167 mg/day for sertraline and 180 mg/day for placebo. Subjects who were treated with sertraline showed significantly greater improvement than placebo on the Y-BOCS (-6.8 and -3.4, respectively; P = 0.005), NIMH-GOCS (-2.2 and -1.3, respectively; P = 0.02), and CGI-I (2.7 and 3.3, respectively; P = 0.002). The authors reported a small number of dropouts because of adverse events and overall found sertraline to be a safe, well-tolerated treatment for this age group. In children and adolescents treated with sertraline over 12 months (at doses between 50-200 mg/daily over 52 weeks), evidence suggests that acute response can convert to full or partial remission of symptoms with longer-term treatment (Wagner et al. 2003).

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