Pharmacokinetics And Disposition

As demonstrated in Table 13-2, considerable pharmacokinetic variability exists within the SSRI class (Leonard 1992). Of particular note, discussion of drug half-life must also include consideration of the presence or absence of active metabolites. Fluoxetine is extensively metabolized by the liver's cytochrome P450 (CYP) system to its active metabolite, norfluoxetine. Fluoxetine is a potent CYP2D6 inhibitor, and norfluoxetine has a moderate inhibitory effect on CYP3A4 (Hemeryck and Belpaire 2002). The elimination half-life of norfluoxetine (4-16 days) is significantly longer than that of fluoxetine (4-6 days); in fact, norfluoxetine's half-life is the longest of any of the SSRIs or their active metabolites (see Table 13-2). Half-life is not significantly affected by hemodialysis or renal impairment (Aronoff et al. 1984).

TABLE 13-2. A comparison of several selective serotonin reuptake inhibitors
Nicotine Support Superstar

Nicotine Support Superstar

Stop Nicotine Addiction Is Not Easy, But You Can Do It. Discover How To Have The Best Chance Of Quitting Nicotine And Dramatically Improve Your Quality Of Your Life Today. Finally You Can Fully Equip Yourself With These Must know Blue Print To Stop Nicotine Addiction And Live An Exciting Life You Deserve!

Get My Free Ebook


Post a comment