The pleiotropic and often profound effects (e.g., neuronal growth, differentiation, survival) of neurotrophins and growth factors in the CNS are generally mediated by varying degrees of activation of three major signaling pathways: MAP kinase (extracellular response kinase [ERK]) pathway, the phosphoinositol-3 kinase pathway, and the phospholipase C->1 pathway (see Figure 1-9). Among these pathways, the effects of the pi3k pathway and the MAP kinase pathway have been most directly linked to the cell survival effects of neurotrophins (Patapoutian and Reichardt 2001).
Was this article helpful?
Stop Nicotine Addiction Is Not Easy, But You Can Do It. Discover How To Have The Best Chance Of Quitting Nicotine And Dramatically Improve Your Quality Of Your Life Today. Finally You Can Fully Equip Yourself With These Must know Blue Print To Stop Nicotine Addiction And Live An Exciting Life You Deserve!