Signaling Cascades Generally Utilized by Neurotrophic Receptors in the CNS

The pleiotropic and often profound effects (e.g., neuronal growth, differentiation, survival) of neurotrophins and growth factors in the CNS are generally mediated by varying degrees of activation of three major signaling pathways: MAP kinase (extracellular response kinase [ERK]) pathway, the phosphoinositol-3 kinase pathway, and the phospholipase C->1 pathway (see Figure 1-9). Among these pathways, the effects of the pi3k pathway and the MAP kinase pathway have been most directly linked to the cell survival effects of neurotrophins (Patapoutian and Reichardt 2001).

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