In this chapter, we reviewed several electrophysiological techniques and preparations used in the analysis of nervous system function. Each approach is characterized by a set of unique advantages and potential shortcomings inherent in the method. Nonetheless, it should be apparent that no single technique has an overwhelming advantage in psychopharmacological research. Instead, by matching the preparation to the question at hand, and through the judicious comparison of data obtained from intact versus isolated preparations, the various limitations may be systematically overcome to yield a more broadly applicable model of psychopharmacological action.

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