Of Biomaterials

1.1. The first reports 3

Chapter 2. FROM FINGERPRINTING TO STRUCTURAL INVESTIGATION 9

2.1. Operational fingerprinting; a new concept 9

2.2. Complexity of the sample 9

2.3. Additivity of component spectra 10

2.4. Availability of reference spectra 10

2.5. Availability of standard reference materials 11

2.6. Knowledge of relevant pyrolysis mechanisms 13

2.7. Availability of ancillary analytical methods 13

Chapter 3. PYROLYSIS MECHANISMS IN BIOMATERIALS 15

3.1. General aspects 15

3.2. Polysaccharides 16

3.3. Nucleic acids 19

3.4. Proteins 21

3.6. Miscellaneous biopolymers 25

Chapter 4. THE TECHNIQUE OF CURIE-POINT PYROLYSIS MASS SPECTROMETRY ... 29

4.1. Sample preparation 29

4.2. Pyrolysis 33

4.3. Pyrolysate transfer 37

4.4. Ionisation 41

4.5. Mass analysis 42

4.6. Ion detection 45

4.7. Signal recording 45

Chapter 5. REPRODUCIBILITY IN CURIE-POINT PYROLY.SIS MASS SPECTROMETRY . . 47

5.1. Qualitative reproducibility 47

5.2. Quantitative reproducibility 49

5.3. Factors influencing long-term reproducibility 50

5.4. Prospects for inter-laboratory reproducibility 52

Chapter 6. DATA ANALYSIS PROCEDURES 55

6.1. Available computer programs 55

6.2. Data pre-processing 56

6.2.1. Pattern scaling 56

6.2.2. Feature scaling 58

6.3. Univariate statistical analysis 60

6.4. Multivariate statistical analysis 62

6.5. Visualisation techniques 66

6.6. Computer-assisted chemical interpretation 68

6.6.1. Subtraction techniques 68

6.6.2. Factor analysis 69

6.7. Computer-assisted quantitative analysis of mixtures 70

6.8. Future developments 73

Chapter 7. SELECTED APPLICATIONS TO BIOMATERIALS 77

7.1. Scope of analytical pyrolysis techniques 77

7.2. Medical applications 77

7.2.1. Clinical microbiology 77

7.2.2. Other clinical applications 83

7.2.3. Quality control 85

7.3. Biological applications 86

7.4. Environmental applications 89

7.5. Biogeochemical applications 92

Was this article helpful?

0 0

Post a comment