Over Medication

Arnun d-

the-Clock

Medication

Ideal Breakthrough Medication

Figure IV-18. Schematic presentation of breakthrough pain and its treatment using the oral transmucosal fentanyl citrate (OTFC) lozenge

25% Rapid OT

absorption

50% To bioavailability r

25% Slow GI

absorption

50% Lost to metabolism or not absorbed

Figure IV-19. Total fentanyl bioavailability with fentanyl OTFC is 50%. Adapted from [33]

pain. The buccal formulation of buprenorphine in dosages of 0.4-08 mg/tablet represents another possibility to treat breakthrough pain when the patient uses transdermal buprenorphine treatment.

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