Ideal Breakthrough Medication
Figure IV-18. Schematic presentation of breakthrough pain and its treatment using the oral transmucosal fentanyl citrate (OTFC) lozenge
25% Rapid OT
50% To bioavailability r
25% Slow GI
50% Lost to metabolism or not absorbed
Figure IV-19. Total fentanyl bioavailability with fentanyl OTFC is 50%. Adapted from 
pain. The buccal formulation of buprenorphine in dosages of 0.4-08 mg/tablet represents another possibility to treat breakthrough pain when the patient uses transdermal buprenorphine treatment.
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