Rationale For The Use Of Opioids

Based on such knowledge, the need for a sufficient pain therapy is inevitable. However, such changes in nociceptive transmission ask for "pre-emptive", or rather "preventive"-analgesia. Opioids are agents, which after binding to and a conformational change of their respective receptor site result in secondary inhibition of adenylcy-clase (AC) are able to prevent calcium inflow through voltage-dependent ion channels (Figure I-45).

7-lrar»mombrane Kchj

Cj protein-coupled rctcpior

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