Based on such knowledge, the need for a sufficient pain therapy is inevitable. However, such changes in nociceptive transmission ask for "pre-emptive", or rather "preventive"-analgesia. Opioids are agents, which after binding to and a conformational change of their respective receptor site result in secondary inhibition of adenylcy-clase (AC) are able to prevent calcium inflow through voltage-dependent ion channels (Figure I-45).
Cj protein-coupled rctcpior
Was this article helpful?
Free Your Mind And Achieve Peace. Discover How To Live In Peace And Harmony In A World Full Of Uncertainty And Dramatically Improve Your Quality Of Life Today. Finally You Can Fully Equip Yourself With These “Must Have” Tools For Achieving Peace And Calmness And Live A Life Of Comfort That You Deserve.