Biology

Although it was initially assumed that SQ-109 (9c) and EMB (9a) would share the same arabinosyltransferase target, which catalyzes the transfer of arabinosyl residues to the cell wall arabinogalactan polymer, SQ-109 retained potency against EMB resistant strains. In addition, transcriptional profiling studies and analyses of cell wall-linked sugar residues indicated that MTb responds differently to these compounds, suggesting that SQ-109 acts on a different target than EMB [271, 272].

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