Nucleosides 421 History

Nucleoside analogs are a class of drugs typically used in the treatment of infectious diseases and cancer. The requirement for drugs that have activity against MDR-TB and XDR-TB makes the nucleoside analogs particularly attractive, since they have unique mechanisms of action from currently used antitubercular drugs. Among the nucleoside analogs currently under investigation, the capuramycin and caprazamy-cin classes of antibacterial antibiotics have the most potent activity [286]. Capra-zamycin (Fig. 26; 18a-g) and capuramycin (Fig. 27; 19a) are natural products originally isolated from the culture broth of Streptomyces griseus 447-S3 [287] and culture broth of Streptomyces sp. MK730-62F2 [288] and show in vitro activity against drug-resistant MTb strains.

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