The Diseases

This chapter will focus on providing a general overview of DDW, to provide background information to those new to the field, and to serve as an introduction to the following chapters. The following chapters of this volume describe, in a disease-specific manner, the current status of DDW drug discovery of select diseases, specifically tuberculosis, malaria diseases produced by kinetoplastids, dengue, and diarrhea (Chaps. 2-6, respectively). In addition, interested readers may find additional information regarding disease burden, pathogenicity, unmet medical need, treatment, drug pipeline, etc. from the web pages and reports from the WHO, including a Global Health Observatory Map Gallery (http://gamapserver. who.int/mapLibrary/app/searchResults.aspx) and a WHO report on NTDs (http:// whqlibdoc.who.int/publications/2010/9789241564090_eng.pdf). The public-private partnerships (PPPs) Web sites have additional reports and information dedicated to different aspects of these diseases (Table 4).

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