Molecular Profiling Identifies Deregulated Expression of Multiple ETS Family Transcription Factors in Prostate Cancer

Maurizia Mello Grand, Maria Scatolini, Francesco Acquadro and Giovanna Chiorino (Fondo Edo Tempia- Biella, ITALY), Veronica Albertini, Afua Mensah, Carlo V Catapano, Giuseppina M Carbone (IOSI - Bellinzona, Switzerland)

Prostate cancer is one of the most common neoplasia in men. This cancer is clinically and genetically heterogeneous and varies in his biological aggressiveness. We performed gene expression profiling on 93 human prostate samples including 17 normal biopsies, 67 clinically localized adenocarcinomas of the peripheral zone of the gland and 9 benign prostatic hyperplasia (BPH). Comparative hybridization of tissues against a commercially available normal prostate reference was realized using oligonucleotide glass arrays with sequences representing over 18,000 well-characterized human genes, in a dye-swap duplication scheme. The aims of the study were: to identify genes involved in carcinogenesis; to improve the histological classification with molecular data; to discover diagnostic and prognostic biomarkers to detect and/or anticipate the clinical evolution of the cancer by correlating gene expression profiles with follow-up data. We also focused on a family of transcription factors whose activation or inhibition could have an important role in the development of the disease. Gene profiling of tumors was matched with histopathological and clinical data and aberrant expression of several ETS family genes was identified at distinct disease stages and patient subgroups. Collectively, molecular profiling suggested a potential role of multiple ETS members in prostate cancer pathogenesis.

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